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apalutamide will lessen the level or effect of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a robust CYP2C19 inducer, with medications that are CYP2C19 substrates may result in decrease exposure to these medications.Impact of coadministration of a twin CYP3A4 and C